Saturday, June 16, 2012

SHILAJIT - Scientific Research, Reviews and Patents

SHILAJIT - Scientific Research, Reviews and Patents
US Patent No: 8,173,181: Method and composition for improved anabolism
Anabolism is a key factor in the process of muscle growth for athletes and body builders. Anabolism is comprised of multiple metabolic pathways, constructing larger molecules from their building blocks. Energy is a necessary part of these metabolic pathways. In contrast, catabolism is the deconstruction of large molecules into smaller ones. Anabolism is fueled by both the small molecules of catabolism as well as an energy source, such as, but not limited to, adenosine triphosphate (ATP). The anabolic process and related anabolic hormones stimulate protein synthesis and muscle growth. 
Anabolic reactions are synthesis reactions and are endergonic, meaning that they consume more energy than they produce. Anabolism is the process of chemical reactions that combine simple molecules and monomers to form the body's complex structural and functional components. Glucose may take part in or be formed via several anabolic reactions such as, for example, synthesis of glycogen or the synthesis of new glucose molecules from byproducts of protein and lipid breakdown, i.e., gluconeogenesis.
One way of promoting anabolism is through the use of a dietary supplement or drug. However, many anabolic stimulation compositions are illegal or have been banned from use by athletes in a number of professional, collegiate, and amateur sports. Additionally, anabolic stimulating products also generally tend to have undesired side effects that can be harmful to the health of an individual. Thus, there is a need and a demand for a dietary ingredient or composition which can promote anabolism without undesirable side effects and/or which is suitable for use by athletes.

 
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For the most part, anabolism is increased where there is an energy source and a way to synthesize proteins and therefore build new muscle.
Shilajit moomiyo is an adaptogenic herb which can be used to enhance physical and mental performance. Shilajit is believed to amplify the benefits of other herbs by enhancing their bio-availability. Shilajit is also believed to increase anabolism protein synthesis, growth rate and/or energy intake. Suitably, the nutritional composition can include a Shilajit material or extract which has been standardized to include or contain 10% fulvic acid. In accordance with certain other embodiments, the nutritional composition can alternatively and/or additionally contain fulvic acid, humic acid, and/or another botanical, natural, or herbal source of fulvic acid and/or humic acid. 


US Patent No: 8,110,230: Phytoceutical compositions for the prevention and treatment of circulatory disorders, feminine endocrine disorders, and dermal disorders
Shilajit (Mumiyo) Mumiyo is a natural complex substance, whose active principles are carboxylic acids: (hydroxylated derivatives of Benzoic, Phenylacetic and Hippuric acids), fulvic and humic acids, minerals and amino acids. Of Mumiyo's known properties, the most important ones are its ability to reduce excessive inflammatory reactions and stimulate tissue regeneration. Oral intake of Mumiyo has been used to treat burns, trophic non-healing wounds, eczema, and other skin diseases, such as psoriasis. It has been established that fulvic/humic acids stimulate respiration and oxidative phosphorylation in liver mitochondria, increase mechanical resistance of collagen fibers, activate human leucocytes, reduce excessive inflammatory reactions, and stimulate tissue regeneration. 


US Patent No: 7,982,066: Method for chromatographic finger printing and standardization of single medicines.
Shilajit is a carbonaceous material that forms due to storage of vegetable and animal matter inside the earth for many years. Mostly due to lava floated over a forest destroying flora and fauna. This after undergoing many geological changes becomes carbonaceous material called Shilajits. It is abundantly available in Himalayan mountains of India and parts of Russia. one of the very important medicines used in Indian System of medicine Silajit, is reported to have many compounds along with fulvic acids, and is claimed to be active principle. As this medicine from bituminous source is collected from earth stored for many years, it can be seen that the more it is in stored in the earth, the more it will be therapeutically active. Nevertheless, in the entire globe, the geological variations may not produce same molecules in all samples collected from different parts of the world. Another factor that influences the chemistry of these drugs is the purification process, which also needs to be standardized.



US Patent No: 7,250,181: Polyherbal compositions and methods for treating viral infections and boosting immunity. The present invention relates to pharmaceutical or veterinary or nutritional compositions of polyherbal extracts useful as anti-viral or immune-supporting agents. Particularly, the present invention of polyherbal composition comprises of extracts of Withania somnifera, Mangifera indica and purified Shilajit.  Additionally, this composition is used for the treatment, prevention or management of immune-supporting system in primates in need, especially humans 

 
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Shilajit is regarded as a panacea in many traditional systems of medicine, practiced worldwide. While many regard Shilajeet as a potent immunomodulator and antioxidant, very few know what are the major bioactive constituents present in Shilajit. Purified Shilajit of the present invention composed of three distinct classes of bioactive compounds: (A) Low- and medium-Mw (mol. wt.) non-humic organic compounds, comprising free and conjugated (e.g., fattyacyl, aminoacyl, lipoidal) DBPs; (B) dibenzo-alpha-pyrones chromoproteins (DCPs) comprising: (i) dibenzo-alpha-pyrones or their derivatives, (ii) phosphocreatine, (iii) chromo-peptides of molecular weights of about .ltoreq.2 KD and (iv) lipids having fatty acyl esters of glycerol; and (C) fulvic acids of low to medium molecular weight (Mn about 700 to 2,000). The fulvic acids are polymeric units of 3,8-oxygeneated dibenzo-alpha-pyrone (or derivatives) repeat units. 
US Patent No: 6,869,612: Process for preparing purified shilajit composition from native shilajit .
 
Rejuvenating changes in one's body can be initiated and effected by nutrition, herbs and herbo-minerals. Aging and its associated problems are a degenerative disease, which, however, is preventable and treatable. The aging process involves the action of highly reactive free radicals, produced systemically, which interact with other cellular compounds and produce oxidative damages and eventually kills cells and tissues and impairs the immune function of the organism. Such free radical damage accumulates and increases with age, creating degenerative diseases, such as Alzheimer's, cardiovascular, arthritis, cancer and over a hundred other diseases.
DNA, the cellular building block of the body, is very sensitive to oxidative stress. Although repairs to damaged DNA are constantly being made, the cell's mechanism cannot keep up with the number of mutations that occur in the organism, particularly in the aged. Mitochondria, the part of the cell that is responsible for producing cellular energy, has its own DNA, but it does not have a repair mechanism to give it protection against free radical induced damage. The mutation of mitochondrial DNA therefore produces a greater adverse effect than DNA mutation elsewhere in the system. Researchers in recent years have shown that certain individual natural supplements, such as omega-3-polyunsaturated fatty acids and metabolites thereof, oxygenated dibenzo-.alpha.-pyrones, and their O-acylesters, as well as hydroxyacetophenones and fulvic acids can protect against oxidative damage to mitochondrial DNA.
Accordingly, it is desired in this invention to provide a purified composition of bioactive agents to protect the body against free radical damage.
Native shilajit is a blackish-brown exudation, of variable consistencies, obtained from steep rocks of different formations found in the Himalayas at altitudes between 1000-5000 m, from Arunachal Pradesh in the East, to Kashmir in the West. Shilajit also is found in other mountain ranges of the world, e.g. Afganisthan (Hindukush, Badakh-Shan), Australia (Northern Pollock Ranges), and in the former USSR (Tien-Shan, Pamir, Caucasus, Ural). Native shilajit is believed to arrest aging and also produce rejuvenation, two important attributes of an Ayurvedic rasayan medicine. Considerable controversy, however, has existed in the literature concerning the nature and chemical character of shilajit. It has been variously described as a bitumen (asphalt), a mineral resin, a plant fossil, a substance of mixed plant and animal origin, or an inorganic substance. 

 
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A particular object of this invention is to provide purified shilajit compositions having an abundance of bioactive components, particularly oxygenated dibenzo-.alpha.-pyrones (DBPs), and carrier molecules, which are low-to-medium molecular weight fulvic acids (FAs) present in abundant amounts in the composition.



US Patent No: 6,558,712:  Method of enhancing Fulvuc acid concentration in Shilajith The difference between Shilajit-based fulvic acid (FAs) and alluvial soil-derived fulvic acids lies in the core structures of the fulvic acids (FAs) in these compositions. Shilajit-FAs contains 3,8-oxygenated dibenzo-.alpha.-pyrone as the core nucleus, which, upon repeated oxidation, and Michael addition reactions by nucleophile-containing oxygen, nitrogen and carbon ions, in association with various lipid moieties, produce a multiplayer micellar structure. In contrast, alluvial soil-FAs are composed essentially of aromatic hydroxy acids and polyphenols derived from phenolic oxidations. Both these FAs contain different metal ions, especially Fe, Co, Zn, Ca, etc., associated with the FAs. The metals in Shilajit-FAs are well-organized, multicentered, metal-ion associated products which, in the case of iron, maintains the metal in the reduced state and produce different iron-containing enzymes. Such trace ion-metal associations are not possible for soil-FAs because they have a much less organized heteropolycondensate structure whose micellar structure is irregular.
Another unique feature of Shilajeet-FAs is that it is of endogenous origin produced by animal systems. These systems meet the essential need of bioavailability of trace metals and minerals, which serve as a carrier of essential nutrients in the living animal body. By contrast, soil-FAs, being exogenous in origin, do not contribute to those essential needs of animals.
Silajit-FAs also contains oligomeric (di, tri, tetra) dibenzo-.alpha.-pyrones, which scavenge free radicals and free metal ions, to become a soft-spin radical. In contrast, soil-FAs contain only esters of phenolic acids which do not have the antioxidant activity possessed by Shilajit-FAs.
Significantly, acylated DBP, with a lipid chain, are present in Shilajit-FAs; these actives behave like a liposome (polymicellar structure) which can act as an efficient carrier molecule. The phenolic acid esters present in soil-FAs do not possess these characteristics.
Thus, in accordance with the invention, the purified fulvic acid carrier constituent of native Shilajit, without toxic components, and substantially without bioactive constituents in the voids of the carrier, is provided by a defined extraction procedure from native Shilajit. 



US Patent No: 5,597,585:    Vitamin/mineral composition  A mixture of vitamins, minerals and an esoteric composition from the Far East named "Shilajit", which was a folk remedy for various disorders can treat various cellular deficiencies.



 
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US Patent No: 5,405,613:  A composition comprising Shilajit or an extract thereof in a vitamin and/or mineral preparation. The present invention relates to the use of Shilajit or extracts thereof in vitamin and/or mineral compositions; to vitamin and/or mineral compositions containing Shilajit or extracts thereof; and, to methods to restore energetic balance or intensity, or to support or enhance a bioenergetic field in a mammal using Shilajit or extracts thereof. 
In the Eastern world, a compound known as Shilajit (silajit) has a history of use as a folk remedy for various disorders, including genito-urinary diseases, diabetes, gall stones, jaundice, enlarged spleen, fermentative dyspepsia, worms, digestive disorders, piles, epilepsy, nervous disorders, eczema, anaemia, anorexia, asthma etc. Shilajit has also been used as a tonic to help retain youthful vigour. Shilajit has been administered either by itself or in combination with certain other ayurvedic (herbal) medicines.
Shilajit is a natural exudate ejected from rocks during hot weather in the lower Himalayas, Vindhya and other mountain tracts and Nepal, or it may be a tar formed in the earth from the decomposition of vegetable substances. (See the Indian Materia Medica, pages 23 to 32 for a detailed discussion of the composition and properties of Silajit). It is a compact mass of vegetable organic matter, composed of a gummy matrix interspersed with vegetable fibres and minerals. Substances which have been identified in Shilajeet include moisture, gums, albuminoids, calcium, potassium, nitrogen, silica, resin, vegetable matter, magnesium, sulphur, iron, chloride, phosphorous, iodine, glycosides, tannic acid, and a number of vitamins and enzymes. Shilajit also contains benzoic acid, a compound which, along with its derivatives, has been used as a component of nutritional vitamin and mineral preparations. 
The present inventor has found that Shilajit over and above its nutritional and herbal content has novel energetic properties. Measurement of subtle energy changes indicate that Shilajit has a vibratory field that is substantially stronger than any vitamin, mineral, food substance or herb. Its vibratory field is also stronger than the vibratory fields of any of the known ingredients which make up Shilajit, when these ingredients are tested as pure substances from non-Shilajit sources.
The present inventor has also surprisingly found that when a small amount of Shilajit is added to a vitamin or mineral preparation, the energetic properties of the vitamin or mineral preparation are enhanced. In particular, the present inventor has found that the addition of a small amount of Shilajit to a vitamin or mineral preparation increases the energy field of the entire preparation to at or near the vibratory level of pure Shilajit.
The addition of Shilajit to vitamin or mineral preparations imparts to the preparations an energetic quality above and beyond their nutritional content. As well, the energetic quality of Shilajit-fortified vitamin and mineral preparations support or enhance a user's bioenergetic field.
The present invention therfore relates to the use of Shilajit or extracts thereof in a vitamin and/or mineral preparation to enhance the energy properties of the preparation.
The invention also relates to a composition comprising Shilajit or extracts thereof in a vitamin and/or mineral preparation.
The invention further relates to a method to restore energetic balance or intensity, or to support or enhance a bioenergetic field in a mammal comprising administering to a mammal an effective amount of Shilajit or extracts thereof. Preferably, the Shilajit or extract thereof is administered in a vitamin and/or mineral preparation. 
 
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4 comments:

Royal Bee Natural Products Pvt Ltd. said...

The information which you have provided is very good. It is very useful who is looking for Shilajit Capsules.

Unknown said...

I'm curious as to why your reviews only include pill forms of Shilajit and non that come in tar form like Purblack or Pureshilajit?

Arti Rani said...

शिलाजीत के बारे में जानकारी देने के लिए बहुत धन्यवाद। patanjali Shilajeet को जानने और खरीदने के लिए यह विजिट करे।

Nik said...

I found full information about tar Shilajit here: https://siberian-health.us/